A Comparative clinical study to evaluate the effect of Indigenous compound drugs (Shatavari mandoor and Pippali ghrita) in Parinama Shoola Vis-à-vis Acid Peptic Disorders

Pragya Singhal


Background: : Acid peptic disease is the condition in which there is either excessive secretion of acid and pepsin or a weakened stomach mucosal defence, which is responsible for damage to the delicate mucosa and the lining of the stomach, oesophagus and duodenum resulting in ulceration.Parinama shoola in Ayurveda is comparable with Acid peptic disease.

Aim of study: The Aim of the study is to evaluate and compare the effect of indigenous compound drugs (Shatavari mandoor and Pippali ghrita) in uncomplicated cases of Parinam shoola.

Methods:  This is a prospective, open labelled, randomised clinical trial. A total of 31 patients suggestive of features of Parinama Shoola (acid peptic disorder) were enrolled and were randomly divided in two groups- 12 patients were enrolled in group A and were given trial drug Shatavari mandoor,19 patients were enrolled in group B and were given trial drug Pippali ghrita. Duration of study was 3 months.

Results: Individually both groups showed statistically significant improvement in clinical symptoms i.e. pain in abdomen, epigastric burning, nausea, flatulence, loss of appetite and constipation (p<0.01), but the mean reduction in the symptoms of group A (Shatavari mandoor group) is more than group B (Pippali ghrita group).

Conclusion: Both trial drugs are effective in the treatment of Parinama shoola. Shatavari mandoor is more effective in the treatment of Parinam shoola in comparison to Pippali ghrita.



Acid peptic disorder, epigastric pain, Parinama shoola, peptic ulcer disease

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ISSN No: 0976-5921