Alpha amylase inhibitor as an Anti-diabetic potential from medicinal plants: A Review

Authors

  • Lovepreet Kour
  • Shabnam
  • Ashish Sutee
  • Rattan Deep Singh

DOI:

https://doi.org/10.47552/ijam.v13i4.2836

Keywords:

Diabetes, Alpha amylase inhibitors, Plants, Classification, In-vivo, In-vitro, In- silico approaches

Abstract

Alpha amylases cleave the starch like molecules and led to increase in blood sugar level in diabetic patients then in order to manage it the inhibition action is carried out by their inhibitors. The α-amylase inhibitors catalyses the process of endo-hydrolysis of α (1→ 4) glycosidic linkage present in starch which ultimately led to decrease in the starch hydrolysis process. It also affects the carbohydrate absorption in the intestine. In 1945, the first alpha amylase inhibitor was reported from beans. It has already been isolated from various plant species namely, Hibiscus sabdariffa.L, Geranium pratense L and Cedrus libani A. Rich with inhibition percentage of 100, 43 and 31 respectively. The studies have already been reported on inhibitors and their interactions with human pancreatic alpha amylases are made .In-vitro and in vivo tests has already been done by various researchers which showed a significant drop in blood sugar level of a normoglycemic mice after an extract from the leaves of Bersama abbyssinica was tested for its potential effect as anti-diabetic. 

Author Biographies

Lovepreet Kour

Research Scholar, School of Bioengineering and Biosciences, Lovely Professional University, Punjab. India. 

Shabnam

Research Scholar, School of Bioengineering and Biosciences, Lovely Professional University. Punjab. India. 

Ashish Sutee

Professor, School of Pharmaceutical Sciences, Lovely Professional University, Punjab. India. 

Rattan Deep Singh

Associate Professor, School of Bioengineering and Biosciences, Lovely Professional University. Punjab. India. 

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Published

07-01-2023

How to Cite

Kour, L. ., Shabnam, Sutee, A., & Singh, R. D. (2023). Alpha amylase inhibitor as an Anti-diabetic potential from medicinal plants: A Review. International Journal of Ayurvedic Medicine, 13(4), 925–932. https://doi.org/10.47552/ijam.v13i4.2836