In-silico and in-vitro toxicological evaluation of Tiktakam kashayam

Authors

  • Perumal Pandurangan
  • Rajinikanth B
  • Ayisha H
  • Fahmitha AK
  • Hanna AN
  • Sumy Susan Biju

DOI:

https://doi.org/10.47552/ijam.v13i3.3016

Keywords:

Ayurvedic formulation, Piper longum, Azadiracta indica, Inflammatory bowel disease, Hepatotoxicity

Abstract

“TIKTAKAM KASHAYAM” is evaluated by in-silico study using PASS online software. Its having anti-inflammatory activity and also having anti-neoplastic activity especially colon cancer. In-vitro heavy metal analysis shows lead and mercury below the detection limit, cadmium not detected and arsenic is present below the approved range. Some important toxicities like hepatotoxicity shown by the compound azadirachtin present in Azadiracta indica, neurotoxic shown by the compound biflorne present Inoldenlandia corymbosa, Ototoxicity shown by the compound sweroside, reproductive dysfunction produced by the compound luteolin present in Gentiana kuro. Neurotoxic by kobusone, respiratory failure by swertiamarin, ototoxicity by sweroside present in the plant swertia chirayata. Parkinsonism like effect produced by the compound piperine and   pipperitin by Piper longum. The ayurvedic formulation “TIKTAKAM KASHAYAM” possess anti-inflammatory activity and will be beneficial for the treatment of inflammatory bowel disease.

Author Biographies

Perumal Pandurangan

Professor and HOD, Department of Pharmaceutical Chemistry, The Dale View College of Pharmacy and Research Centre, Punalal, Thiruvananthapuram, Kerala. India.

Rajinikanth B

Professor and HOD, Department of Pharmacology, Grace College of Pharmacy, Palakkad, Kerala. India.

Ayisha H

Department of Pharmacology, Grace College of Pharmacy, Palakkad, Kerala, India.

Fahmitha AK

Department of Pharmacology, Grace College of Pharmacy, Palakkad, Kerala, India.

Hanna AN

Department of Pharmacology, Grace College of Pharmacy, Palakkad, Kerala, India.

Sumy Susan Biju

Department of Pharmacology, Grace College of Pharmacy, Palakkad, Kerala, India.

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Published

09-10-2022

How to Cite

Pandurangan, P., B, R., H, A., AK, F. ., AN, H., & Biju, S. S. (2022). In-silico and in-vitro toxicological evaluation of Tiktakam kashayam. International Journal of Ayurvedic Medicine, 13(3), 783–791. https://doi.org/10.47552/ijam.v13i3.3016

Issue

Vol. 13 No. 3 (2022): July-September 2022

Section

Research Articles

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