TY - JOUR AU - Gadad, Geeta AU - R S, Hiremath AU - U B, Bolmal PY - 2022/07/08 Y2 - 2024/03/28 TI - Development and Evaluation of Antimicrobial Activity of Durva Nishadi Ointment: In-vitro Study JF - International Journal of Ayurvedic Medicine JA - IJAM VL - 13 IS - 2 SE - Research Articles DO - 10.47552/ijam.v13i2.2573 UR - https://ijam.co.in/index.php/ijam/article/view/2573 SP - 400-405 AB - <p><strong>Background</strong>: Synthetic antimicrobials are often associated with adverse effects as a result, there is need for the use of alternate herbal medicines is increasing with their easy availability, safety, cost effectiveness and therapeutic potentiality. In this present study <em>Durva Nishadi</em> Ointment was developed from <em>Durva nishadi Yoga</em> described in Ayurvedic classics as a Lepa (topical application) against microbial diseases like <em>Kandu </em>(Pruritis), <em>Pama </em>(Scabies), <em>Dadru</em> (Tinea/ Ringworm infection), <em>Sheetapitta</em> (Urticarial rashes) and <em>Krimi </em>(Microbial infections).</p><p><strong>Result</strong>: The developed <em>Durva Nishadi</em> ointment has highly significant antifungal activity than the antibacterial activity. Antifungal activity of 20% ointment against <em>Candida albicans</em> was 28mm of zone of inhibition at 25 μg/ ml, and for <em>Aspergillus niger</em> 15 mm of zone of inhibition at 5 μg/ ml, which are highly comparable with the synthetic standard drug used for the antifungal activity i.e. Fluconazole.</p><p>&nbsp;</p><p><strong>Abbreviations</strong></p><p>MIC - Minimum inhibitory concentration, MHA - Muller-Hinton Agar</p><p><strong>&nbsp;</strong></p> ER -