Comparative antimicrobial potential of Tribhuvana-Mishrana and its ingredients against clinical bacteria

Authors

  • Vashisht Kiran Banaras Hindu University
  • Thakur Vivek
  • Kumar Deepak
  • Sharma Khemchand

DOI:

https://doi.org/10.47552/ijam.v8i1.883

Keywords:

Tribhuvana-Mishrana, Tribhuvanakirti Rasa, Godanti Bhasma and Sudarshana Ghana Vati, Antimicrobial activity.

Abstract

There are many single drug and compound formulations prescribed for Jwara (~ fever) in Ayurvedic classics. Tribhuvanakirti Rasa (TKR), Godanti Bhasma (GB) and Sudarshana Ghana Vati (SGV) are widely used compound formulations that are separately indicated for the treatment of Jwara (~fever) in different dosage schedules. In Ayurvedic Formulary of India Tribhuvana-Mishrana (TM) has been chiefly indicated in treatment of Sarva Jwara (~ fever). Therefore, in this study comparative antimicrobial activity of TM and its individual ingredients viz. TKR, GB and SGV were evaluated against four fever-causing microbes such as gram-positive bacteria Staphylococcus aureus and the gram-negative bacteria Salmonella typhii, Escherichia coli and Pseudomonas aeruginosa. The aqueous extract of all the four samples (formulation as whole and the three individual ingredients separately) in a dose 125mcg/ml were tested for their antimicrobial activity against four different microbes by agar well diffusion method. The study shows that TM and its ingredients independently show significant antimicrobial activity. S. aureus was found to be most sensitive to SGV and moderately sensitive to TKR and TM while S. typhii was found to be most sensitive to TM as compared to others. TKR was found to be most effective against E.coli while SGV and TM both showed significant antimicrobial effect against E. coli. TM could provide an alternative to synthetic antibiotics against human microbial infections.

Author Biographies

Vashisht Kiran, Banaras Hindu University

Ph.D.Scholar, Department of Dravya Guna Vigyana, Faculty of Ayurveda, I.M.S, B.H.U, Varanasi, India

Thakur Vivek

P.G. Scholar, P.G. Department of Rasa Shastra & Bhaishjya Kalpana , Uttarakhand Ayurveda University, Rishikul Campus, Haridwar, Uttarakhand, India.

Kumar Deepak

Assistant Professor, Department of Microbiology, IMS, BHU Varanasi, India.

Sharma Khemchand

Prof. MD (Ayu.), PhD, Department of Rasa Shastra & Bhaishjya Kalpana, Uttarakhand Ayurveda University, Gurukul Campus, Haridwar, Uttarakhanda, India.

Downloads

Published

2017-03-26

How to Cite

Kiran, V., Vivek, T., Deepak, K., & Khemchand, S. (2017). Comparative antimicrobial potential of Tribhuvana-Mishrana and its ingredients against clinical bacteria. International Journal of Ayurvedic Medicine, 8(1). https://doi.org/10.47552/ijam.v8i1.883

Issue

Vol. 8 No. 1 (2017): January - March 2017

Section

Research Articles

License

The author hereby transfers, assigns, or conveys all copyright ownership to the International Journal of Ayurvedic Medicine (IJAM). By this transfer, the article becomes the property of the IJAM and may not be published elsewhere without written permission from the IJAM.

This transfer of copyright also implies transfer of rights for printed, electronic, microfilm, and facsimile publication. No royalty or other monetary compensation will be received for transferring the copyright of the article to the IJAM.

The IJAM, in turn, grants each author the right to republish the article in any book for which he or she is the author or editor, without paying royalties to the IJAM, subject to the express conditions that (a) the author notify IJAM in advance in writing of this republication and (b) a credit line attributes the original publication to IJAM.

https://creativecommons.org/licenses/by-nc-sa/4.0/