Effect of Afghan Senjed (Elaeagnus Angustifolia L.) Leaves Aqueous Extract on Memory of Male Rats
Keywords:Afghanistan, Cholesterol, Elaeagnus Angustifolia, Leaves, Memory, Rat
This study is aimed to evaluate the effect of Elaeagnus Angustifolia leaves extract (EALE) on the memory of male rats. Rats were divided into 7 groups: 4 groups in the first stage (Control, EALE 100, 200 and 400 mg/kg) to determine the effective-dose of EALE on memory; and 3 groups in the second stage (Normal, Scopolamine and EALE effective-dose) to evaluate the effect of EALE on scopolamine-induced memory impairment. Rats received EALE by i.p. administration for 14 days and the memory function of all groups was evaluated by the Y-maze test on days 8 and 15. Only scopolamine and effective dose of EALE groups were received scopolamine 30 min before Y-maze test. The total cholesterol and triglyceride levels of stage 2 rats were also measured. On day 8, the percentage of spontaneous alternation (%SA) was significantly increased in EALE 400 mg/kg group, as compared with the control group. On day 15, there was a significant difference in %SA only between EALE 100 mg/kg group and the control group. The %SA was significantly increased in the EALE effective-dose group only on day 15, as compared with scopolamine group (P<0.05). The effective-dose of EALE was also significantly decreased the total cholesterol (P<0.01) and triglyceride (P<0.001) levels in comparison with scopolamine group. In conclusion, a high dose of EALE only in a short-term administration period and its low dose in a long-term administration period had memory-enhancing effects. The low dose of EALE as an effective-dose of EALE could reverse the scopolamine-induced memory impairment.
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