Pharmaceutico-analytical profile of Mrityunjay Rasa and evaluation of its Antibacterial activity

Abstract

Background: Mrityunjay Rasa is the one of the Kharaliya Kalpana explained in Yogaratnakara in Jwara chikitsa and indicated in all types of fever. Any pathology can leads to diseases which are easily seen by fever as a clinical symptom. Bacterial infections through the skin or by any system defiantly reflect through fever and as told in classics Mrityunjay Rasa is having the capacity to eradicate all types of Jwara. Aim & Objective: The study is planned to evaluate the antibacterial activity of Mrityunjay Rasa. Material and methods: Mrityunjay rasa was prepared according to Yogratnakar at the Department of Rasashastra & Bhaishajya Kalpana. The formulation was tested for organoleptic characters, physicochemical parameters and microbial specification tests. Observation and results: Standard Mrityunjay rasa can be prepared from three Bhawana of Ardraka swarasa each for an average of 11.55 hrs. Prepared Mrityunjay rasa was Reddish in color with a specific smell and 145.57% average yield.  Analytical standards for Mrityunjay rasa such as loss on drying at 105^oC, total ash, acid insoluble ash, alcohol soluble extractives, water-soluble extractive, pH, Hardness, Disintegration time and particle size were 2.10%, 15.87%, 2.43%, 2.29%, 20.43 %, 8.7 (10% aqueous solution), 3, 30 minutes 20 sec and 95.41  respectively. Mrityunjay Rasa has shown a better zone of inhibition against Staphylococcus aureus. Conclusion: Analytical parameters obtained through the present study can be considered as a reference standard for Mrityunjay rasa.