Traditional uses, phytochemistry and pharmacology of Croton bonplandianum - A review

Abstract

Croton bonplandianum L. (Euphorbiaceae) has been widely used in traditional medicine for a wide range of ailments likejaundice, acute constipation, abdominal dropsy, dysentery, external wounds, hypercholesterolemia, hypertension, and infectious disorders. This aim of the present study is to comprehend the fragmented information available on the traditional uses, phytochemistry, pharmacology of C. bonplandianum to explore its therapeutic potential and futureresearch opportunities. All the available information on C. bonplandianum was collected via electronic search (using Google Scholar, Scopus, Pubmed, and SciFinder) and a library search. Traditional uses of C. bonplandianum are recorded throughout the Asia and South America, where it has been usedfor about various types of disease. The research on bioactive compounds had led to the isolation of diterpenes, alkaloids, flavonoids, steroid glycosides, volatile componentsand some other classes of secondary metabolites fromC. bonplandianum. Extracts and bioactive constituents of C. bonplandianum exhibited a wide range of pharmacological activitieslike, hepatoprotective, anti-inflammatory, antifungal, wound healing, antimicrobial, antioxidant, and anti-tumor.C. bonplandianum emerged as a rich source of traditional medicine for the treatment of various disease although variousin vitro and in vivo studies validated its traditional medicinal uses.