Evaluation of Anti-Hyperglycaemic activity of Ethanolic Extract of Stems of Bryophyllum pinnatum against Type 2 Diabetic rats
Keywords:Antidiabetic, Wistar rats, Ethanol, Glucose, Biochemical markers
To evaluate antidiabetic activity of stems of Bryophyllum pinnatum in Alloxan male Wistar rats cause diabetes. Thirty albino rats were divided into distinct five groups (n=6). By Intraperitoneal injection caused the onset of diabetes of Alloxan (120mg/Kg). vehicle control, negative control, 200, and 400mg/kg ethanolic extracts were given orally in 28 days as single administrations to the vehicle control, diabetic control, normal group, and test groups. Glucose, (fasting and post prandial for 1st and 21st day) serum cholesterol, Triglyceride, HDL (High density lipoprotein), LDL (Low density lipoprotein) Serum creatinine and urea were estimated with blood tests. The student's t test was performed to evaluate the results. In diabetic rats, a low dose of ethanol extract 200mg/kg significantly decreased all biochemical markers of diabetes. A 400mg/kg of ethanol extract was given to diabetic rats and showed substantial decreases in blood glucose and biochemical parameters. Both ethanol high and low dose extracts show antidiabetic activity in Alloxan induced diabetes.
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