Evaluation of the role of Shodhana (Purification) process in Croton tiglium seeds for reduction of toxic content

Authors

  • Ajay Kumar Meena
  • Poorna Venkataraman
  • Ravindra Singh
  • Kusuma Ganji
  • Murali Krishna C
  • Srikanth N

DOI:

https://doi.org/10.47552/ijam.v12i3.2089

Keywords:

Ayurveda, Purification, Crotonoside, LC-MS, GC-MS

Abstract

In Ayurvedic texts, Jayapala or croton tiglium seeds are well known as khumbini for its toxicity (severe purgative action) and are used for the treatment of constipation after shodhana (detoxification) of the seed with godugdha (cow milk). The oil content of the seeds was responsible for the purgative property, and its reduction enhances its medicinal usage. The presence of Crotonoside or iso-guanosine in seed extract was identified in HPTLC and quantified using high pressure liquid chromatography technique both before and after the purification process of the seed. The phytochemicals and physicochemical parameters of seeds were analyzed to find the level of changes in the processed seeds. The other chemical constituents of the seed extracts are studied using different techniques like HPTLC, HPLC, LC-MS, and GC-MS. The study has revealed that the detoxification process, as per classical texts, has shown an effective depletion in the quantity of crotonoside in processed seeds.

Author Biographies

Ajay Kumar Meena

Research officer Chemistry, Regional Ayurveda Research Institute, Aamkho, Gwalior.

Poorna Venkataraman

Captain Srinivasa Murthy Central Ayurveda Research Institute, Chennai. 

Ravindra Singh

Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India, New Delhi. 

Kusuma Ganji

Captain Srinivasa Murthy Central Ayurveda Research Institute, Chennai. 

Murali Krishna C

Regional Ayurveda Research Institute,  Payakapuram, Vijaywada. 

Srikanth N

Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India, New Delhi. 

Downloads

Published

29-09-2021

How to Cite

Meena, A. K., Venkataraman, P., Singh, R., Ganji, K., C, M. K., & N, S. (2021). Evaluation of the role of Shodhana (Purification) process in Croton tiglium seeds for reduction of toxic content. International Journal of Ayurvedic Medicine, 12(3), 565–575. https://doi.org/10.47552/ijam.v12i3.2089

Issue

Section

Research Articles