In-Silico Computational Screening of Siddha formulations Visha Sura Kudineer and Adathodai Kudineer against RNA dependent RNA polymerase of SARS CoV-2

Authors

  • Panneerselvam N R
  • Anbarasan B

DOI:

https://doi.org/10.47552/ijam.v12i3.2125

Keywords:

Docking study, RdRp, Siddha formulation, Visha Sura Kudineer, Adathodai Kudineer, Viral replication

Abstract

Background: Siddha Medicine is an important therapeutic option used for treating various respiratory viral infections and has antiviral herbs. Aim: The study aims to perform the In Silico computational studies of Phytoconstituents of Siddha formulation Visha Sura Kudineer and Adathodai Kudineer which are commonly used in the treatment of viral fever and respiratory tract infections and could be effective against the novel coronavirus disease. Methods: Autodock program was used for the molecular docking studies against RNA-dependent RNA polymerase (RdRP) (PDB ID: 6NUR). Results: A total of 9 compounds were screened, of these 4 compounds namely, Andrographolide of Visha Sura Kudineer and Anisotine, Apioside, and 1-(p-Methoxybenzoyl) aziridine of Adathodai Kudineer showed high binding affinity against RdRp. Conclusion: Based on further experiments and clinical trials, formulations Visha Sura Kudineer and Adathodai Kudineer could be effective in the treatment of COVID-19.

Author Biographies

Panneerselvam N R

Professor, Department of Kuzhanthai Maruthuvam, Sri Sairam Siddha Medical College and Research Centre, Sai Leo Nagar,  Tambaram West, Chennai. 

Anbarasan B

Lecturer, Department of Maruthuvam, National Institute of Siddha, Tambaram Sanatorium, Chennai. 

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Published

29-09-2021

How to Cite

R, P. N., & B, A. (2021). In-Silico Computational Screening of Siddha formulations Visha Sura Kudineer and Adathodai Kudineer against RNA dependent RNA polymerase of SARS CoV-2. International Journal of Ayurvedic Medicine, 12(3), 534–537. https://doi.org/10.47552/ijam.v12i3.2125

Issue

Vol. 12 No. 3 (2021): July - September 2021

Section

Research Articles

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