Ventoluft Polyherbal formulation modulates Freund’s Complete Adjuvant induced arthritis in experimental rats

Authors

  • Nikita A Sadalage
  • Nayeem A Khatib
  • Sunil S Jalalpure
  • Shrinivas Patil
  • Mrityunjaya B Ullagaddi

DOI:

https://doi.org/10.47552/ijam.v12i3.2132

Keywords:

Anti-arthritic activity, Freund’s Complete Adjuvant, Rheumatoid arthritis, Paw edema, Ventoluft

Abstract

Background: Ventoluft Polyherbal formulation composes multiple traditional medicinal plants composed of various anti-inflammatory agents. Hence, the present study aimed to investigate the effect of Ventoluft Polyherbal formulation on Freund’s complete adjuvant-induced arthritic male Wistar rats. Materials and methods: The study included thirty-six rats, containing six in each. Arthritis was induced by injecting FCA (0.1ml) in joints of the right sub-plantar region of rats in negative control and all test groups i.e. (20, 40, and 80mg/kg p.o) for 28 days except normal group. A positive control, indomethacin (10mg/kg, i.p.) was also tested for 28 days. During the treatment, paw volume was measured weekly once. At the end of the experiment, physical, hematological, and biochemical effects were evaluated. Results:Administration of Ventoluft at the doses of 20, 40, and 80 mg/kg b.w. p.o exhibited statistically significant (p < 0.001) inhibition of the paw edema and joint swelling, along with an increase in body weight, decrease in rheumatoid and spleen index factors. Conclusion: The results from hematological and biochemical parameters have shown that Ventoluft possesses potent anti-arthritic activity, Results obtained in the present study indicate that Ventoluft formulation has exhibited, dose-dependent improvement in FCA induced rheumatoid arthritis. 

Author Biographies

Nikita A Sadalage

Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi. 

Nayeem A Khatib

Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi. 

Sunil S Jalalpure

Department of Pharmacognosy and Phytochemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi. 

Shrinivas Patil

Shri Ayurveda Clinic Opposite. Ajanta Hotel, RPD Cross, Tilkawadi Belagavi.

Mrityunjaya B Ullagaddi

Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi. 

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Published

29-09-2021

How to Cite

Sadalage, N. A., Khatib, N. A., Jalalpure, S. S., Patil, S., & Ullagaddi, M. B. (2021). Ventoluft Polyherbal formulation modulates Freund’s Complete Adjuvant induced arthritis in experimental rats. International Journal of Ayurvedic Medicine, 12(3), 523–528. https://doi.org/10.47552/ijam.v12i3.2132

Issue

Section

Research Articles