Antihyperglycemic effects of Amrtottara Kvatha, an Ayurvedic polyherbal formulation in streptozotocin-induced diabetic rats by suppressing oxidative stress

Authors

  • Asok Kumar Jayasree Anand
  • Neenthamadathil Mohandas Krishnakumar
  • Somasekharan Nair Rajam Suja
  • Panickamparambil Gopalakrishnan Latha
  • Jollykutty Eapen
  • Sreedharan Nair Rajasekharan

Keywords:

Anti-diabetic, Glucose tolerance, Glibenclamide, Malondialdehyde, Normoglycemic

Abstract

Amrtottara Kvatha [KNM3] (AK) is a widely used Ayurvedic preparation, primarily utilized for hyperpyrexia (‘Jwara’). In the present study we evaluated the antidiabetic effect of AK against streptozotocin (STZ) induced diabetic murine model. The effects of AK on normoglycemic rats and glucose tolerance were also studied. The antidiabetic effect of AK was evaluated in streptozotocin (STZ, 55 mg/kg, i.p.) induced diabetic rats. AK was administered orally at four doses AK (1/4), AK (1/2), AK (T) and AK (DD) for fourteen days to examine the antidiabetic activity with glibenclamide (5 mg/kg) as reference standard. The effect of AK on blood glucose and insulin levels, biochemical parameters, oxidative stress biomarkers and histopathological examinations were studied. Oral administration of AK at doses AK (1/4), AK (1/2), AK (T) and AK (DD) to rats with streptozotocin induced diabetes showed significant (P<0.01) decrease in blood glucose levels with improved insulin levels, liver glycogen and pancreatic protein content. The oxidative stress biomarkers (malondialdehyde and advanced oxidation protein products) were reduced in all AK treated groups with a significant (P<0.01) increase in antioxidant enzyme status. Histopathological studies also supported the findings. The present study reports for the first time the antidiabetic effects of Amrtottara Kvatha by suppressing oxidative stress induced by streptozotocin in Wistar rats. 

Author Biographies

Asok Kumar Jayasree Anand

PG Scholar, Department of Dravyagunavijnanam, Government Ayurveda College, Thiruvananthapuram, Kerala. India. 

Neenthamadathil Mohandas Krishnakumar

Scientist-B, Department of Biosciences, Rajagiri College of Social Sciences (Autonomous), Kalamassery, Kochi, Kerala. India.

Somasekharan Nair Rajam Suja

Principal Scientist and Head, Ethnomedicine and Ethnopharmacology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute (JNTBGRI), Palode, Thiruvananthapuram, Kerala. India.

Panickamparambil Gopalakrishnan Latha

Former Director, Jawaharlal Nehru Tropical Botanic Garden and Research Institute (JNTBGRI), Palode, Thiruvananthapuram, Kerala. India.

Jollykutty Eapen

Director, Directorate of Ayurveda Medical Education, Kerala. India. 

Sreedharan Nair Rajasekharan

Senior Project Consultant and Director-grade Scientist (Rtd.), Ethnomedicine and Ethnopharmacology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute (JNTBGRI), Palode, Thiruvananthapuram, Kerala. India.

Downloads

Published

08-07-2022

How to Cite

Asok Kumar Jayasree Anand, Neenthamadathil Mohandas, . K., Rajam Suja, S. N. ., Gopalakrishnan Latha, P. ., Eapen, J. ., & Rajasekharan, S. N. . (2022). Antihyperglycemic effects of Amrtottara Kvatha, an Ayurvedic polyherbal formulation in streptozotocin-induced diabetic rats by suppressing oxidative stress. International Journal of Ayurvedic Medicine, 13(2), 443–450. Retrieved from https://ijam.co.in/index.php/ijam/article/view/2620

Issue

Section

Research Articles