Pharmaceutical development of polyherbal Kushthaghna Mahakashaya lotion with FTIR and HPTLC characterization

Abstract

Introduction: Kushthaghna Mahakashaya is a traditional herbal group of ten medicaments (dashemani) explained in classical texts and administered in the form of kashaya (decoction) indicated for the management of Kushtha (skin ailments). In the present scenario, based on disadvantages of the kashaya like lesser shelf-life, cumbersome, difficult to prepare and administer on a daily basis. Furthermore, if it is administered by an external route then, it may avoid first-pass metabolism and thereby enhancing the drug’s bioavailability and causing its rapid action. So, the present study is an attempt to prepare and analyze the modified dosage form of Kushthaghna Mahakashaya Kwatha in the form of Kushthaghna Mahakashaya Lotion. Materials and methods: Kushthaghna Mahakashaya Churna, Ghana, and Lotion were all prepared. Lotion was made by mixing the aqueous and oil phases together at the same temperature. It was stabilized with Carbopol and neutralized with Triethanolamine to improve the sample's stability. Different trials were conducted to check the excipient ratio in the formulation, and samples were evaluated according to standards. Organoleptic parameters, physico-chemical analysis, FTIR, HPTLC, and microbiological specification tests were all performed on the Ghana and Lotion. Results: All the tests and observations were carried out on Kushthaghna Mahakashaya Ghana and Lotion samples, and the results were recorded. Conclusion: Kushthaghna Mahakashaya Lotion can be prepared from Kushthaghna Mahakashaya Kwatha. The prepared lotion will be light brown in colour, characteristic smell and semi-liquid in consistency with good spreadibility.