Acute toxicity study of the nanoparticles of Bauhinia variegata Linn bark hydro-alcoholic extract in Wistar Albino rats

Authors

  • Yakshi Choudhary
  • Shailesh V Deshpande
  • Sandeep B Patil
  • Atul L Chaudhari

DOI:

https://doi.org/10.47552/ijam.v13i3.2895

Keywords:

Ayurveda, Kanchanar, Nanomedicine, Mountain ebony, Herbal medicine

Abstract

Background: Bauhinia variegate Linn is a popular herb used as medicine in traditional health sciences in Southeast Asia. Traditional medicines if used in newer dosage forms such as nanoparticles, can help in reducing the dose, assuring quality, and reducing exploitation of natural resources. However, the safety of medicines needs to be established before use in humans.

Objective: To evaluate the acute toxicity of nanoparticles of Bauhinia variegate Linn bark hydro-alcoholic extract (NBVBE) in Wistar Albino rats on the basis of OECD guidelines 423.

Methodology: The study was conducted using six Wistar albino rats divided into two groups of three rats each. Test rats were given a single dose of 2000 mg/kg body weight of NBVBE orally, while the control group received feed and water ad libitum.

Results: The data indicated no significant changes in weight, complete blood count, or renal and hepatic function when compared with control (p > 0.05). Histopathological examination shows some reversible changes such as steatosis and lymphoid hyperplasia in the rat’s liver and intestine. LD50 for NBVBE is higher than 2000 mg/kg body weight.

Conclusion: NBVBE is safe at 2000 mg/kg body weight. However, monitoring the status of the liver is necessary.

 

 

 

 

 

Author Biographies

Yakshi Choudhary

PG Scholar, Department of Kayachikitsa, Parul Institute of Ayurved, Parul University, Vadodara, Gujarat, India.

Shailesh V Deshpande

Professor, Department of Kayachikitsa, Parul Institute of Ayurved, Parul University, Vadodara, Gujarat, India.

Sandeep B Patil

Associate Professor, Department of Pharmacology, Dr. Shivajirao Kadam College of Pharmacy, Sangli, Maharastra, India.

Atul L Chaudhari

PG Scholar, Department of Kayachikitsa, Parul Institute of Ayurved, Parul University, Vadodara, Gujarat, India. 

Downloads

Published

09-10-2022

How to Cite

Choudhary, Y., Deshpande, S. V., Patil, S. B. ., & Chaudhari, A. L. . (2022). Acute toxicity study of the nanoparticles of Bauhinia variegata Linn bark hydro-alcoholic extract in Wistar Albino rats. International Journal of Ayurvedic Medicine, 13(3), 777–782. https://doi.org/10.47552/ijam.v13i3.2895

Issue

Vol. 13 No. 3 (2022): July-September 2022

Section

Research Articles

License

Copyright (c) 2022 International Journal of Ayurvedic Medicine

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The author hereby transfers, assigns, or conveys all copyright ownership to the International Journal of Ayurvedic Medicine (IJAM). By this transfer, the article becomes the property of the IJAM and may not be published elsewhere without written permission from the IJAM.

This transfer of copyright also implies transfer of rights for printed, electronic, microfilm, and facsimile publication. No royalty or other monetary compensation will be received for transferring the copyright of the article to the IJAM.

The IJAM, in turn, grants each author the right to republish the article in any book for which he or she is the author or editor, without paying royalties to the IJAM, subject to the express conditions that (a) the author notify IJAM in advance in writing of this republication and (b) a credit line attributes the original publication to IJAM.

https://creativecommons.org/licenses/by-nc-sa/4.0/