Acute toxicity study of the nanoparticles of Bauhinia variegata Linn bark hydro-alcoholic extract in Wistar Albino rats
Keywords:Ayurveda, Kanchanar, Nanomedicine, Mountain ebony, Herbal medicine
Background: Bauhinia variegate Linn is a popular herb used as medicine in traditional health sciences in Southeast Asia. Traditional medicines if used in newer dosage forms such as nanoparticles, can help in reducing the dose, assuring quality, and reducing exploitation of natural resources. However, the safety of medicines needs to be established before use in humans.
Objective: To evaluate the acute toxicity of nanoparticles of Bauhinia variegate Linn bark hydro-alcoholic extract (NBVBE) in Wistar Albino rats on the basis of OECD guidelines 423.
Methodology: The study was conducted using six Wistar albino rats divided into two groups of three rats each. Test rats were given a single dose of 2000 mg/kg body weight of NBVBE orally, while the control group received feed and water ad libitum.
Results: The data indicated no significant changes in weight, complete blood count, or renal and hepatic function when compared with control (p > 0.05). Histopathological examination shows some reversible changes such as steatosis and lymphoid hyperplasia in the rat’s liver and intestine. LD50 for NBVBE is higher than 2000 mg/kg body weight.
Conclusion: NBVBE is safe at 2000 mg/kg body weight. However, monitoring the status of the liver is necessary.
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