Evaluation of efficacy of locally delivered Herbal extract in treatment of Chronic periodontitis –A Randomised controlled trial

Authors

  • Shweta B Maske
  • Surekha Rathod
  • Abhay Kolte
  • Pranjali Bawankar
  • Madhur Gupta
  • Supriya Kaule

DOI:

https://doi.org/10.47552/ijam.v14i2.2950

Keywords:

8-hydroxyguanosine, Gingival crevicular fluid, Local drug delivery, Ocimum sanctum, Oxidative stress, Reactive oxygen species

Abstract

Background: Various locally delivered agent are used as an adjunct to scaling and root planning (SRP). 8- Hydroxydeoxyguanosine (8-OHdG) is best documented biomarker of oxidative stress in periodontitis. Objective: To evaluate the efficacy of locally delivered Ocimum sanctum gel by assessing the levels of 8-OHdG in Gingival crevicular fluid (GCF) of smokers and nonsmokers with periodontitis. Material and Methods: The study included 50 patients divided into 3 groups, group I - periodontally healthy, group II- smokers with stage II periodontitis and group III- non-smokers with stage II periodontitis. Smokers and non-smokers with stage II periodontitis received the locally delivered 10% OS gel as an adjunct to SRP at the test site at baseline and after 1 week recall, while SRP alone at control site. Result: 8-OHdG GCF levels were analyzed with enzyme-linked immunosorbent assay (ELISA) at baseline, and 6-months follow up. Probing pocket depth (PPD) in test site significantly reduced to 2.75 ±0.64, 2.50 ±0.68 at 6 month after periodontal therapy in group 2 and 3 respectively. Similarly, clinical attachment level (CAL) in test site significantly reduced to 3.15 ±0.81, 2.85 ±0.93 at 6 month after periodontal therapy in group 2 and 3 respectively. Conclusion: The application of 10% Ocimum sanctum L. gel showed significant improvement in PPD, CAL and PI and GI and reduction in GCF 8-OHdG levels.

Author Biographies

Shweta B Maske

VSPM Dental College and Research Centre, Nagpur, India.

Surekha Rathod

Professor, Department of Periodontics and Implantology, VSPM Dental College and Research Centre, Nagpur, India.

Abhay Kolte

Professor and Head, Department of Periodontics and Implantology VSPMDental College and Research Centre, Nagpur, India.

Pranjali Bawankar

Senior Lecturer, Department of Periodontics and Implantology VSPMDental College and Research Centre, Nagpur, India.

Madhur Gupta

Head, Department of Biochemistry, NKP Salve Institute of Medical Sciences, Nagpur, India.

Supriya Kaule

Junior Resident, VSPM Dental College and Research Centre, Nagpur, India

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Published

03-07-2023

How to Cite

Maske, S. B., Rathod, S., Kolte, A. ., Bawankar, P., Gupta, M. ., & Kaule, S. (2023). Evaluation of efficacy of locally delivered Herbal extract in treatment of Chronic periodontitis –A Randomised controlled trial. International Journal of Ayurvedic Medicine, 14(2), 380–387. https://doi.org/10.47552/ijam.v14i2.2950

Issue

Section

Research Articles