A pilot study to observe the progression of Vyadhi Samprapti in Srotas in the context of Hypothyroidism

Abstract

In chronic conditions, the progression of samprapti (pathogenesis) of Hypothyroidism in various Srotasas (Body Channels) can be observed due to the lack of Nidanparivarjanam (restraining of etiological factor) and Shuddha-Chikitsa (Comprehensive treatment). Assessment of the progression of the pathogenesis of Hypothyroidism in the Srotasas would help to decide the treatment plan for Hypothyroidism according to the stage of the disease, which prevents the further progression of the disease and drug dependency. Objectives: Observe the progression of the pathogenesis of Hypothyroidism in the Srotasas by assessing signs and symptoms of the Dhatupradoshaja Vikara (diseases due to vitiation of dhatu) along with their severity. Methods: In a cross-sectional study, 50 patients with chronicity of hypothyroidism for more than 1 year and on therapy were selected randomly and categorized into 5 groups, according to their chronicity. A separate case proforma was designed to focus on the assessment of the progression of the pathogenesis in patients of Hypothyroidism. The signs and symptoms described as Dhatupradoshaja Vikara, chronicity of hypothyroidism, findings of Thyroid Function Test (total serum thyroid-stimulating hormone, serum, total serum triiodothyronine, total serum thyroxine,) and drug dosage were recorded in each patient. The data was subjected to statistical tests.  Results: It is observed that the extent of signs and symptoms of Dhatupradoshaja Vikaras increased with the chronicity of Hypothyroidism in study participants. Progression of Samprapti of hypothyroidism in further Srotasa was observed in patients with chronicity of Hypothyroidism, especially in individuals with Avar Agni (weak state of digestive and metabolic factors). It is observed that in the study participant drug dosages were escalated with chronicity and Avara Agnibala (weak state of Agni).  Rasadhatu and Rasavaha Srotas along with Medodhatu and Medovaha Srotas are priorly and predominantly get vitiated in the Samprapti while other Dhatus and Dhatuvaha Srotasa are involved in Samprapti over the period. Conclusion: It can be concluded that the vyadhi samprapti of Hypothyroidism progresses in further Srotasa with the chronicity of hypothyroidism.