Insilico evaluation of pharmacological activities of Kalarchi Chooranam

Authors

  • Vetriselvi V
  • Bharathajothi P

DOI:

https://doi.org/10.47552/ijam.v13i4.3119

Keywords:

Kalarchi Chooranam, Siddha medicine, PCOS, Molecular Docking

Abstract

The Indian traditional medicine practices such as siddha and ayurveda records various medicinal plants for the betterment of human health. Recent reports shows that this system of medicine has potential plants and formulation to treat various diseases and ailments. In the present study, we extracted and prepared the Kalarchi Chooranam of various ratios and chosen 4:1 ratio from our previous work. The aqueous extract of 4:1 ratio Kalarchi Chooranam was subjected to GCMS study and the compounds Inositol, Xanthosine (CAS), alpha.-D-Glucopyranoside, methyl 2,3-bis-O- were identified as lead 3 compounds. The Xanthosine (CAS), alpha.-D-Glucopyranoside, methyl 2,3-bis-O- have passed the drug likeness and ADME properties and further docked against various receptors involved in disease pathogenesis such as cancer (Bcl2, Bcl-X), PCOS (Cyp17, Follistatin), Inflammation & Analgesic (Cox1, Cox2), and Diabetics & Cardiovascular diseases (Er Alpha, Er Beta). The overall study reveals that the compounds have more binding affinities against the poly cystic ovarian syndrome receptors as the Xanthosine showed significant binding energies of -8.9 and -8.2 Kcal/mol and the Alpha.-D-Glucopyranoside, methyl 2,3-bis-O showed -8.2 and -9.7 Kcal/mol against CYP17 and Follistatin. The Kalarchi Chooranam has to be studied more reveal all its pharmacological activities.

Author Biographies

Vetriselvi V

Department of Siddha Medicine, Tamil University, Thanjavur, Tamil Nadu, India. 

Bharathajothi P

Department of Siddha Medicine, Tamil University, Thanjavur, Tamil Nadu, India.

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Published

07-01-2023

How to Cite

V, V., & P, B. (2023). Insilico evaluation of pharmacological activities of Kalarchi Chooranam. International Journal of Ayurvedic Medicine, 13(4), 991–996. https://doi.org/10.47552/ijam.v13i4.3119

Issue

Section

Research Articles