Probable mode of action of Sida Cordifolia in Dyspareunia an In-Silico network Pharmacological approach

Abstract

Dyspareunia, a painful sexual disorder can be correlated to Paripluta yonivyapath (disorders of the genital tract) as per Ayurveda classics, which comes under the category of Female sexual dysfunction, the less explored clinical field in Ayurveda. Bala, Sida cordifolia Linn is the single drug that is directly indicated in this disease condition. This is the era in which the whole medical world is running behind in standardizing Evidence-based medicine (EBM) in clinical application. Network pharmacology, a branch of science that combines Network biology and polypharmacology, which predicts the mode of action of therapeutic drugs on both the interactome and the diseasome level. Here is an attempt to put forth the therapeutic efficacy of Bala in Dyspareunia through network pharmacology and bonding energy was demonstrated by molecular docking. Methods: Phytochemicals of Bala were collected from the IMPPAT database and related research articles. The disease targets were obtained from databases namely the Therapeutic target database, ChEMBL, Human protein atlas, and DisGeNet. The therapeutic efficacy of these gene targets in dyspareunia is confirmed and the conclusion is obtained from the network pharmacological ligand-target interaction methodology. The ligands and targets were retrieved from the PubChem, Protein Data Bank and docked using PyRx software. Results and Conclusion: The current study identified important Phyto-constituents like Resin Acid, Malvalic Acid, 5,7-Dihydroxy-3-Isoprenyl Flavones, Peganine, Β-Phenethylamine, Ψ-( Pseudo) -Ephedrine, Coronaric Acid, Potassium Nitrate, Phenethylamine, Ephedrine, Choline which were highly modulating CYP19A1, ESR2, MAPK1, AR, MAPK3, ESR1, CYP19A1, PGR proteins related with Dyspareunia.