Chronic toxicity studies of Tuttha bhasma (CuSO4.5H2O) in Wistar Albino Rats

Authors

  • Muralidhar R Ballal
  • Shrinidhi R
  • Ravi M

DOI:

https://doi.org/10.47552/ijam.v13i4.3184

Keywords:

Sub-acute toxicity, Tuttha bhasma, Atherosclerosis, Histopathology, Cell infiltration, Anemia

Abstract

Abstract

Tuttha Bhasma (TB) is an important metal based drug used in Ayurveda. It has widespread therapeutic uses in the treatment of metabolic disorders. Despite of its therapeutic utility there is a lack of data related to its safety. Hence the present study was undertaken to evaluate chronic toxicity of TB in Wistar albino rats. Chronic toxicity study was conducted as per AYUSH guidelines 170 and the parameters such as ponderal changes; biochemical, hematological and histopathological examinations were recorded. Based on the overall toxicity profile significant changes in the serum SGPT was noted in therapeutic and higher dose levels. We could see the serum cholesterol, SGOT, SGPT and albumin levels were significantly elevated at lower dose compared to the control group.  Histopathology of kidney showed cell infiltration and sections from liver showed mild to moderate fatty changes at higher dose levels. Histopathology of jejunum revealed there was mild to moderate epithelial erosion and shortening of epithelial layer. However overall toxicity study parameters showed the test drug TB is well tolerated and no dose dependent toxicity symptoms were observed. Based on the findings we could conclude that Tuttha bhasma is much safer to use at therapeutic dose level. However, at higher dose levels there are chances of organ toxicity.

Author Biographies

Muralidhar R Ballal

Professor, Department of Rasashastra and Bhaishajya Kalpana and Head of Sri Dharmasthala Manjunatheshwara College of Ayurveda, Kuthpady, Udupi 574118, India.

Shrinidhi R

Associate Professor, Department of Agadatantra, Sri Dharmasthala Manjunatheshwara College of Ayurveda, Kuthpady, Udupi.  India.

Ravi M

Department of Pharmacology, Adichunchanagiri Institute of Medical Sciences, BG Nagar, Mandya, Karnataka, India. 

Downloads

Published

2023-01-07

How to Cite

Ballal, M. R., R, S., & M, R. (2023). Chronic toxicity studies of Tuttha bhasma (CuSO4.5H2O) in Wistar Albino Rats. International Journal of Ayurvedic Medicine, 13(4), 884–890. https://doi.org/10.47552/ijam.v13i4.3184

Issue

Vol. 13 No. 4 (2022): October - December 2022

Section

Research Articles

License

Copyright (c) 2022 International Journal of Ayurvedic Medicine

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The author hereby transfers, assigns, or conveys all copyright ownership to the International Journal of Ayurvedic Medicine (IJAM). By this transfer, the article becomes the property of the IJAM and may not be published elsewhere without written permission from the IJAM.

This transfer of copyright also implies transfer of rights for printed, electronic, microfilm, and facsimile publication. No royalty or other monetary compensation will be received for transferring the copyright of the article to the IJAM.

The IJAM, in turn, grants each author the right to republish the article in any book for which he or she is the author or editor, without paying royalties to the IJAM, subject to the express conditions that (a) the author notify IJAM in advance in writing of this republication and (b) a credit line attributes the original publication to IJAM.

https://creativecommons.org/licenses/by-nc-sa/4.0/