Evaluation of the analgesic activity of quercetin and chrysin in animal models

Abstract

Pain is relieved by analgesics that acts via modulating the central and peripheral pain mediators. Some of the analgesic has been reported to have a serious adverse effects when used in long-term treatments. Therefore, there is a need of developing a potent analgesic with minimal of no adverse effects. In the current study, quercetin and chrysin were evaluated for the analgesic activity in mice and rat by hyperalgesia (Eddy’s hot plate and Tail flick analgesiometer). Diclofenac and tramadol was used as a standard reference drugs. Male Swiss Albino mice and rats are divided into six groups and treated with vehicle (1% acacia), quercetin (40 mg/kg), chrysin (100 mg/kg), chrysin (200 mg/kg), diclofenac (10 mg/kg) and tramadol (10 mg/kg) orally. In the present study, diclofenac, tramadol, quercetin and chrysin significantly increased the tail flick latency in the tail flick pain model compared to control group. Chrysin showed remarkable analgesic activity at 200 mg/kg compared to 100 mg/kg in Tail Flick and Eddy’s hot plate model. The current study also reported that diclofenac has more analgesic activity than tramadol on both 1^st and 7^th day of treatment.