Antidiabetic potential of Guizotia Abyssinica cass seed oil in Wistar Albino rats - An experimental approach
Keywords:Quercetin, Chrysin, Diclofenac, Tramadol, Hyperalgesia, Analgesics, Analgesiometer
Guizotia abyssinica Cass. widely grown plant of southern India, seed oil of which are said to be healthy source of oil. Diabetes mellitus is a metabolic disorder affecting major population worldwide. Nutritive healthy source of oils and fats are essential in current scenario. Hence antidiabetic property of Guizotia abyssinica Cass seed oil is tested in Streptozotocin induced diabetes in Wistar albino Rats. Materials and methods: Test drug collected, authenticated, seed oil prepared. Study was conducted in Wistar albino Rats inducing diabetes with Intra peritoneal injection of Streptozotocin. The animals under different test groups received Glibenclamide as standard drug; single and Double dose of G. abyssinica Cass seed oil as test drug and the effect was observed by analysing serum glucose, lipid profile, weight of the Liver and histopathological changes in liver and pancreas after 21 days of experiment. Results: Test drug disclosed decrease in the Serum Sugar level. It has also shown decrease in total cholesterol, LDL and not showed the significant increase in HDL. Histopathological observation of Liver and pancreas proved safety aspect of the drug by preventing the cytotoxic effect of STZ.
How to Cite
Copyright (c) 2022 International Journal of Ayurvedic Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
The author hereby transfers, assigns, or conveys all copyright ownership to the International Journal of Ayurvedic Medicine (IJAM). By this transfer, the article becomes the property of the IJAM and may not be published elsewhere without written permission from the IJAM.
This transfer of copyright also implies transfer of rights for printed, electronic, microfilm, and facsimile publication. No royalty or other monetary compensation will be received for transferring the copyright of the article to the IJAM.
The IJAM, in turn, grants each author the right to republish the article in any book for which he or she is the author or editor, without paying royalties to the IJAM, subject to the express conditions that (a) the author notify IJAM in advance in writing of this republication and (b) a credit line attributes the original publication to IJAM.