Antidiabetic potential of Guizotia Abyssinica cass seed oil in Wistar Albino rats - An experimental approach

Abstract

Guizotia abyssinica Cass. widely grown plant of southern India, seed oil of which are said to be healthy source of oil. Diabetes mellitus is a metabolic disorder affecting major population worldwide. Nutritive healthy source of oils and fats are essential in current scenario. Hence antidiabetic property of Guizotia abyssinica Cass seed oil is tested in Streptozotocin induced diabetes in Wistar albino Rats. Materials and methods: Test drug collected, authenticated, seed oil prepared. Study was conducted in Wistar albino Rats inducing diabetes with Intra peritoneal injection of Streptozotocin. The animals under different test groups received Glibenclamide as standard drug; single and Double dose of G. abyssinica Cass seed oil as test drug and the effect was observed by analysing serum glucose, lipid profile, weight of the Liver and histopathological changes in liver and pancreas after 21 days of experiment. Results: Test drug disclosed decrease in the Serum Sugar level. It has also shown decrease in total cholesterol, LDL and not showed the significant increase in HDL. Histopathological observation of Liver and pancreas proved safety aspect of the drug by preventing the cytotoxic effect of STZ.