Traditional Indian Medicine Improves Clinical Outcome in Non-alcoholic fatty Liver diseases - A Systematic Review and Meta-analysis

Authors

DOI:

https://doi.org/10.47552/ijam.v14i2.3395

Keywords:

Ayurveda, Herbal Medicine, Non- Alcoholic Fatty Liver Disease, Meta-analysis, Systematic Review, Yakrit Roga

Abstract

Background: Non- Alcoholic Fatty Liver Disease (NAFLD) is a rapidly emerging liver disease linked strongly to metabolic syndrome. In the absence of specific pharmacological agents for the effective treatment of NAFLD, current treatment mainly focuses on lifestyle and dietary modifications. Several agents referenced in Ayurvedic texts have shown promising effects in patients over centuries of use. But the outcomes reported by various randomized clinical trials (RCTs) for the efficacy of herbs in non-alcoholic fatty liver disease (NAFLD) are conflicting. Objective: This study aims to systematically review and conduct meta-analysis of the available evidence to evaluate the efficacy and safety of Ayurveda-referenced drugs.  Methodology: The electronic databases PubMed, Web of Science, Embase, Cochrane library, and ARP were searched up to May 2022 to identify relevant studies. Quality of studies was evaluated using modified Jadad Scale. Risk of bias was assessed using Cochrane risk of bias tool. Result: The search retrieved 1352 studies, but only 18 studies were finally evaluated. Statistical analysis showed significant reduction in grades of fatty liver (RR: 2.42, 95% CI; 1.52, 3.86), AST (SMD: -0.91, 95% CI; -1.04, 0.08;) and ALT (SMD = − 0.91; 95% CI; − 1.53, − 0.28; P < 0.00001). Conclusion: Ayurveda drugs have shown positive results in managing NAFLD, as evidenced by the limited available data. More quality-based RCT’s using standardized Ayurveda drugs with large sample sizes and taking histological outcomes into consideration must be conducted to generate stronger evidence.

Author Biographies

Piyush Chaudhary

Assistant Professor, MSM Institute of Ayurveda, Bhagat Phool Singh Mahila Vishwavidyalaya, Khanpur Kalan, Sonipat, Haryana. India.

Bharat Rathi

Professor, Datta Meghe Institute of Medical Sciences, Wardha, India.

Neha Lamba

Assistant Professor, Shri Krishna Government Ayurveda College, Kurukshetra, Haryana. India.

Anil Sharma

Professor, Shri Krishna Government Ayurveda College, Kurukshetra, Haryana. India.

Renu Rathi

Professor, Datta Meghe Institute of Medical Sciences, Wardha, India.

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Published

03-07-2023

How to Cite

Chaudhary, P., Rathi, B., Lamba, N., Sharma, A., & Rathi, R. (2023). Traditional Indian Medicine Improves Clinical Outcome in Non-alcoholic fatty Liver diseases - A Systematic Review and Meta-analysis. International Journal of Ayurvedic Medicine, 14(2), 308–316. https://doi.org/10.47552/ijam.v14i2.3395

Issue

Section

Review Articles