Anti-obesity effect of peel of Opuntia joconostle Web in high-fat-diet-induced obesity C57BL/6J mice


  • Rosa Martha Perez Gutierrez



Opuntia joconostle Web, Obesity, Flavonoids, Phenolic compounds


Obesity is directly associate to cancer, diabetes, cardiovascular diseases and hypertension  producing severe complication of  health and economic costs  in  a global scale. This study aims to validate the anti-obesity potential of the peel of Opuntia joconostle hydroethanolic extract  (XOCO) on obesity in high-fat diet (HFD)-induced obese C57BL/6 mice. Therefore, the phenolic compounds and flavonoids  profiles were investigated by colorimetric assay. We are using a HFD  induced obesity in mice and after orally administered 200, 300 and  mg/kg XOC for 5 weeks. At the end of the experimental period was determined body weight, food intake, serum biochemical parameters,  fat weight, organ and a histological analysis.  This research demonstrated that the peel of the investigated  xoconostle had a significantly amount of flavonoids, showing  highest level of total phenolic compound  (58.15 mg GAE/g  of extract) and flavonoid content (59.12 mg CE/g of extract). XOC Treatment in HFD-fed mice decreases adipogenesis, total body fat, the absolute body weight, lipidemia, glucose levels,  leptin, and resistin, and increases HDL-CHO levels and adiponectin. In histological analysis showed  inhibition of the deposition of fat droplets in the liver. Findings indicated  that XOC  has anti-obesity effects in obesity-induced mice. This potential anti-obesity effect  may be due to phenolic compounds content in the extract.

Author Biography

Rosa Martha Perez Gutierrez

Laboratorio de Investigación de Productos Naturales. Escuela Superior de Ingeniería Química e Industrias Extractivas. Instituto Politécnico Nacional (IPN) Unidad Profesional Adolfo López Mateos S/N Av. Instituto Politécnico Nacional Ciudad de México, CP 07708, México




How to Cite

Perez Gutierrez, R. M. (2023). Anti-obesity effect of peel of Opuntia joconostle Web in high-fat-diet-induced obesity C57BL/6J mice. International Journal of Ayurvedic Medicine, 14(1), 157–161.



Research Articles