Anti-obesity effect of peel of Opuntia joconostle Web in high-fat-diet-induced obesity C57BL/6J mice
Keywords:Opuntia joconostle Web, Obesity, Flavonoids, Phenolic compounds
Obesity is directly associate to cancer, diabetes, cardiovascular diseases and hypertension producing severe complication of health and economic costs in a global scale. This study aims to validate the anti-obesity potential of the peel of Opuntia joconostle hydroethanolic extract (XOCO) on obesity in high-fat diet (HFD)-induced obese C57BL/6 mice. Therefore, the phenolic compounds and flavonoids profiles were investigated by colorimetric assay. We are using a HFD induced obesity in mice and after orally administered 200, 300 and mg/kg XOC for 5 weeks. At the end of the experimental period was determined body weight, food intake, serum biochemical parameters, fat weight, organ and a histological analysis. This research demonstrated that the peel of the investigated xoconostle had a significantly amount of flavonoids, showing highest level of total phenolic compound (58.15 mg GAE/g of extract) and flavonoid content (59.12 mg CE/g of extract). XOC Treatment in HFD-fed mice decreases adipogenesis, total body fat, the absolute body weight, lipidemia, glucose levels, leptin, and resistin, and increases HDL-CHO levels and adiponectin. In histological analysis showed inhibition of the deposition of fat droplets in the liver. Findings indicated that XOC has anti-obesity effects in obesity-induced mice. This potential anti-obesity effect may be due to phenolic compounds content in the extract.
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