In-vitro anti-inflammatory and anti-oxidant study of Sansevieria cylindrica Bojer ex. Hook and Plumeria obtusa L. plants using different methods

Authors

  • Sunil Shewale
  • Vaishali Undale
  • Vrushali Bhalchim
  • Vinita Patole
  • Snehal Satpute
  • Surabhi Jarare
  • Sakshi Sonawane

DOI:

https://doi.org/10.47552/ijam.v14i2.3555

Keywords:

Sansevieria cylindrica, Plumeria obtusa, Albumin denaturation, Anti-inflammatory, Anti-oxidant

Abstract

Background: Sansevieria cylindrica and Plumeria obtusa are used as a medicinal plant during intentional and unintentional accidental injuries. However, limited investigations have been performed to study pharmacological activities of these plants. Objectives: The current study designed at examining in-vitro anti-inflammatory and anti-oxidant effect of both plant extracts. Material & Method: Initially, the collection and authentication of both the plants performed. Phytochemical screening was done thereafter. Sansevieria cylindrica leaves and Plumeria obtusa seed pods were extracted using a combination of water and ethanol. Anti-inflammatory effect was assessed using membrane stabilization and protein denaturation assays. Anti-oxidant activity was measured by free radicals scavenging method using different reactive oxygen species producing reagents. Results: The dose dependent increase in anti-inflammatory and anti-oxidant activities were reported by both plants. Overall, Sansevieria cylindrica has shown higher rate of prevention of inflammation and oxidation compared to Plumeria obtusa extract. Both plants showed comparable anti-inflammatory and anti-oxidant activity in combination with that of reference drugs. Conclusion: The hydro-alcoholic extracts of Sansevieria cylindrica and Plumeria obtusa individually and also as 1:1 blend might be responsible for an anti-inflammatory and anti-oxidant activities. 

Author Biographies

Sunil Shewale

Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule University of Pune. Pune-411018, Maharashtra (India)

Vaishali Undale

Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences, and Research, Savitribai Phule University of Pune. Pune-411018, Maharashtra (India).

Vrushali Bhalchim

Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule University of Pune. Pune-411018, Maharashtra (India).

Vinita Patole

Department of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule University of Pune. Pune-411018, Maharashtra (India).

Snehal Satpute

Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule University of Pune. Pune-411018, Maharashtra (India).

Surabhi Jarare

Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule University of Pune. Pune-411018, Maharashtra (India).

Sakshi Sonawane

Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Savitribai Phule University of Pune. Pune-411018, Maharashtra (India).

 

 

Downloads

Published

03-07-2023

How to Cite

Shewale, S., Undale, V., Bhalchim, V. ., Patole, V., Satpute, S., Jarare, S., & Sonawane, S. (2023). In-vitro anti-inflammatory and anti-oxidant study of Sansevieria cylindrica Bojer ex. Hook and Plumeria obtusa L. plants using different methods. International Journal of Ayurvedic Medicine, 14(2), 527–535. https://doi.org/10.47552/ijam.v14i2.3555

Issue

Section

Research Articles