Anti-hypertensive effect of Siddha formulation Imbural Vadagam against Human angiotensin converting enzyme using In-Silico model

Authors

  • Bharathy K
  • Dhivya G
  • Lakshmi Kantham T
  • Meena Kumari R

DOI:

https://doi.org/10.47552/ijam.v14i2.3641

Keywords:

Siddha Medicine, Imbural vadagam, Hypertension, Angiotensin converting enzyme inhibitor, Docking study, ACE

Abstract

Background: Siddha Medicine is emerging as the treatment of choice for various diseases. Hypertension is one among the comorbidities which plays a major role leading to stroke, cardiovascular diseases and renal failure.  Objective: To perform the In Silico computational studies of phytocomponents of Imbural vadagam and to evaluate its anti-hypertensive potential. Methods: Auto dock program was used for the molecular docking studies against Angiotensin Converting Enzyme(ACE). Results: Asperulosidic acid, 6α-Hydroxygeniposide, Piperic acid, Piperine, Apigenin, Orientin and Vitexin that exist in the siddha drug Imbural vadagam exhibit remarkable binding against the target Angiotensin converting enzyme. Conclusion: It can be that these phytocomponents exhibit remarkable antihypertensive activity. 

Author Biographies

Bharathy K

PG scholar, Department of Maruthuvam, National institute of Siddha, Tambaram sanatorium, Chennai 47, Tamil Nadu, India.

Dhivya G

PG scholar, Department of Maruthuvam, National institute of Siddha, Tambaram sanatorium, Chennai 47, Tamil Nadu, India.

Lakshmi Kantham T

Associate Professor, Head of the Department (i/c), Department of Maruthuvam, National institute of Siddha, Tambaram Sanatorium, Chennai 47, Tamil Nadu, India.

Meena Kumari R

Director, Head of the Department, Department of Gunapadam, National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamil Nadu, India.

Downloads

Published

2023-07-03

How to Cite

K, B., G, D., T, L. K. ., & R, M. K. (2023). Anti-hypertensive effect of Siddha formulation Imbural Vadagam against Human angiotensin converting enzyme using In-Silico model. International Journal of Ayurvedic Medicine, 14(2), 469–473. https://doi.org/10.47552/ijam.v14i2.3641

Issue

Vol. 14 No. 2 (2023): April - June 2023

Section

Research Articles

License

Copyright (c) 2023 International Journal of Ayurvedic Medicine

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

The author hereby transfers, assigns, or conveys all copyright ownership to the International Journal of Ayurvedic Medicine (IJAM). By this transfer, the article becomes the property of the IJAM and may not be published elsewhere without written permission from the IJAM.

This transfer of copyright also implies transfer of rights for printed, electronic, microfilm, and facsimile publication. No royalty or other monetary compensation will be received for transferring the copyright of the article to the IJAM.

The IJAM, in turn, grants each author the right to republish the article in any book for which he or she is the author or editor, without paying royalties to the IJAM, subject to the express conditions that (a) the author notify IJAM in advance in writing of this republication and (b) a credit line attributes the original publication to IJAM.

https://creativecommons.org/licenses/by-nc-sa/4.0/