Anti-hypertensive effect of Siddha formulation Imbural Vadagam against Human angiotensin converting enzyme using In-Silico model

Authors

  • Bharathy K
  • Dhivya G
  • Lakshmi Kantham T
  • Meena Kumari R

DOI:

https://doi.org/10.47552/ijam.v14i2.3641

Keywords:

Siddha Medicine, Imbural vadagam, Hypertension, Angiotensin converting enzyme inhibitor, Docking study, ACE

Abstract

Background: Siddha Medicine is emerging as the treatment of choice for various diseases. Hypertension is one among the comorbidities which plays a major role leading to stroke, cardiovascular diseases and renal failure.  Objective: To perform the In Silico computational studies of phytocomponents of Imbural vadagam and to evaluate its anti-hypertensive potential. Methods: Auto dock program was used for the molecular docking studies against Angiotensin Converting Enzyme(ACE). Results: Asperulosidic acid, 6α-Hydroxygeniposide, Piperic acid, Piperine, Apigenin, Orientin and Vitexin that exist in the siddha drug Imbural vadagam exhibit remarkable binding against the target Angiotensin converting enzyme. Conclusion: It can be that these phytocomponents exhibit remarkable antihypertensive activity. 

Author Biographies

Bharathy K

PG scholar, Department of Maruthuvam, National institute of Siddha, Tambaram sanatorium, Chennai 47, Tamil Nadu, India.

Dhivya G

PG scholar, Department of Maruthuvam, National institute of Siddha, Tambaram sanatorium, Chennai 47, Tamil Nadu, India.

Lakshmi Kantham T

Associate Professor, Head of the Department (i/c), Department of Maruthuvam, National institute of Siddha, Tambaram Sanatorium, Chennai 47, Tamil Nadu, India.

Meena Kumari R

Director, Head of the Department, Department of Gunapadam, National Institute of Siddha, Tambaram Sanatorium, Chennai, Tamil Nadu, India.

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Published

03-07-2023

How to Cite

K, B., G, D., T, L. K. ., & R, M. K. (2023). Anti-hypertensive effect of Siddha formulation Imbural Vadagam against Human angiotensin converting enzyme using In-Silico model. International Journal of Ayurvedic Medicine, 14(2), 469–473. https://doi.org/10.47552/ijam.v14i2.3641

Issue

Vol. 14 No. 2 (2023): April - June 2023

Section

Research Articles

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