A Druggability study to Probe immunomodulatory Unani plants as active Inhibitors of Pseudotyped Particle Cell Entry
Keywords:Druggability, PubChem AID, Unani, ADMET, WEKA, Molecular docking, Bioassay, Immunomodulatory
Medicinal herbs, plants and their products show revolutionized effect in modern therapeutic system. Industries used their activity as antioxidant, antitoxin, antimicrobial, immune booster and many others and use them accordingly as the prime agent to produce cosmetics, food, drug synthesis etc. Unani is one of the traditional therapeutic system which use medicinal herbs mostly for making their herbal medicines. There are several immunomodulatory herbs along with their phytochemicals are present to serve their best. Bioassay is the method of analysis to find out the potency or concentration of any substance when effect on living things. Sars Cov-2 virus and its fatal outbreak is a real threat to modern society. To perform in vitro procedure to screened out small molecule inhibitors of this malicious pseudo typed particle cell entry, Dr. Whittaker's group use this bioassay system like PubChem AID: 1479144, PubChem AID: 1479149, PubChem AID: 1479150 and PubChem AID: 1494158. This in silico study is to show the potency of the phytochemicals of traditional herbs of Unani, as if inhibitors by means of machine learning with the help of WEKA. The ADMET study and molecular docking with Mpro (6lu7 chain A) is also done to test the druggability and binding affinity of the qualified phytochemicals.
How to Cite
Copyright (c) 2023 International Journal of Ayurvedic Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
The author hereby transfers, assigns, or conveys all copyright ownership to the International Journal of Ayurvedic Medicine (IJAM). By this transfer, the article becomes the property of the IJAM and may not be published elsewhere without written permission from the IJAM.
This transfer of copyright also implies transfer of rights for printed, electronic, microfilm, and facsimile publication. No royalty or other monetary compensation will be received for transferring the copyright of the article to the IJAM.
The IJAM, in turn, grants each author the right to republish the article in any book for which he or she is the author or editor, without paying royalties to the IJAM, subject to the express conditions that (a) the author notify IJAM in advance in writing of this republication and (b) a credit line attributes the original publication to IJAM.