Nootropic Effect of Celastrus paniculatus on Restraint Stress Induced Behavioral and Biochemical Changes in Wistar Albino Rats
Keywords:Celastrous paniculatus, Restraint stress, Antioxidant, Behavior, Anxiety
Background: Stress most certainly plays a significant role in everyday life. The natural biological balance is disrupted by stressful events, which has a negative impact on normal physiological and psychological function. In the last 20 years, there hasn't been much advancement in the creation of medications, efficient drug delivery systems, or treatments for Central Nervous System (CNS)-related issues. The ancient Ayurvedic herb Celastrus paniculatus (CP) has been used for millennia as a memory booster, anti-inflammatory, analgesic, sedative, and antiepileptic drug. The neuropharmacological effects of the seed extract have been thoroughly studied in a variety of laboratories, and there are numerous findings that support their nootropic function. Aim: To investigate the effects of Celastrus paniculatus against restraint stress, induced behavioral and biochemical changes in male Wistar albino rats. Methods: The animals were divided into five groups. Each group includes six animals. Group I: Control, Group II: Restraint stress (6hrs for 21 days), Group III: Celastrus paniculatus (400mg/kg, orally) and restraint Stress, Group IV: Celastrus paniculatus alone, Group V: Vehicle. The behavioral changes are assessed by Place Preference test, Elevated plus Maze. Animals were euthanized and the discrete regions of the brain were homogenized for biochemical estimation, such as Catalase, SOD, LPO, GPX, GSH, Vitamin C. Animal’s cognitive and anxiety-related behavior and antioxidants were examined the following day after the stress procedure and treatment. Results: Following a period of 21 days of being subjected to restraint stress, the behavioral changes were reduced in stress group when compared to control group, and also the levels of Lipid peroxidase significant (P<0.05) increased in the restraint stress group as compared to the control group. Enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), Vitamin C, Glutathione experienced a significant (P<0.05) reduction in the restraint stress group as opposed to the control group. Conclusion: Chronic restraint stress has adverse effects on the animal’s cognition, memory, and learning abilities as well as anxiety-related behavior. However, Celastrus paniculatus treatment shows enhanced performance in anxiety-related Behavior and antioxidant properties.
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