Wound Healing Potential of Different Extracts of Ehretia Laevis Roxb. (Khandu Chakka/Ajan Vruksha) Versus Silver Sulfadiazine in Burn Wound - Pre-Clinical Study

Abstract

                      Burns are also a leading cause of morbidity; millions who survive suffer from lifelong disability and disfigurements with resulting emotional trauma and stigma.  To identify the effective extract of Charma Vruksha( Ehretia Laveis Roxb.) in burn wound management and to generate empirical evidence for substantiation of burn wound healing by Kashaya Rasa ( Astringent taste)  through  experimental demonstration of the comparative wound healing property of Charma Vruksha ( Ehretia Laevis Roxb.)  this study was planned. This study is useful in broadening of  therapeutic aspect of Charma Vruksha( Ehretia Laveis Roxb.) plant. This is contribution to the literature related to ayurvedic sciences. The stated side effects of silver sulfadiazine  like pain, burning, itching, rash, cell death, destruction of red blood cells (in patients with G6PD deficiency), deficiency of granulocytes in the blood, low blood platelet count, low white blood cell count , can be minimized to some extent by the use of Charma Vruksha( Ehretia Laveis Roxb.)  plant leaves. Wound healing  measured by  histology score and wound contracture percentages. Average wound contracture  percentage was 36.83 % in Crude Extract group, 33.75% in Ethanol Extract group, 34.6 % in Chloroform Extract group , 42.41% in Aqueous Extract group, as compared to 38.08 %  of  Silver sulfadiazine. Histological score was 16 in Crude Extract group, 15 in Ethanol Extract group,15 in Chloroform Extract group , 16 in Aqueous Extract group as compared to 18 of  Silver sulfadiazine. Aqueous Extract was more effective in burn wound contracture by 11.37 % than Silver sulfadiazine Crude and Aqueous extract was more effective than ethanol and chloroform extract by 1 histological score but less effective by 2 histological score than Silver sulfadiazine.

Aqueous Extract is more efficacious in burn wound contracture by 11.37 % than Silver   sulfadiazine.