Development and Evaluation of Lavangadi Vati in the Form of Suspension- A Polyherbal Novel Liquid Dosage Form

Abstract

Introduction: The demand of the herbal medicine is increasing worldwide due to its lesser toxicity and side effects. Though so many formulations are there in ayurveda, the patient compliance for its palatability and acceptability need to consider. The present study focused on the modification of lavangadi vati into suspension, a liquid dosage form, which is effective in prana vaha sroto vikaras (disorders related to respiratory system) and standardising its quality parameters. Aims: To develop lavangadi vati suspension from the classical lavangadi vati dosage form and standardising the process by the evaluation of the micrometric properties, quality control parameters and TLC finger printing. Materials and Method: Among the six trials, the suspension containing lavangadi vati churna in a dose of 1gm/5ml and 4% sodium CMC as the suspending agent with a specific formula and using suitable excipients were selected as master formula. Result: As per the criteria lavangadi vati shown with particle size of 433.7nm, Haussner ratio with 1.06, Carr’s index about 6% and angle of repose with 28. 77⁰.Lavangadi vati suspension shown a pH in the normal range about 6.28 and having high sedimentation range and good redispersibility. Both the vati and modified suspension almost shown similar bands in TLC. Conclusion: After the evaluation of the various quality control parameters, prepared suspension having appropriate properties of a standard suspension without deviating from the classical lavangadi vati formulation.