Cognition enhancing activity of essential oil of Hedychium coronarium j. Koenig in memory-impaired animal models

Authors

  • Shraddha Mahadev Parab
  • Naikwade NS
  • Shikalgar TS
  • Rutuja Nandkumar Mali

DOI:

https://doi.org/10.47552/ijam.v15i1.4415

Keywords:

Alzheimer’s disease, Hedychium coronarium, antioxidants, Cognition, memory, Degeneration, Anticholinesterase, Antioxidants

Abstract

Alzheimer's disease (AD) is a degenerative neurological condition that causes loss of memory and cognition. Numerous variables, such as age, environment, lifestyle, and genetics, influence the occurrence of such neurodegenerative diseases. Hedychium coronarium j. Koenig is being used traditionally for various skin problems. In, this study, we evaluated the effect of the anticholinesterase and antioxidant activity of the essential oil of Hedychium coronarium j. Koenig by in vitro as well as in vivo tests in Aluminum chloride (AlCl3) induced zebrafish and mouse models of memory impairment. Hedychium coronarium j. Koenig significantly retained the spatial and fear memory in zebrafish and mice. Oral administration of the essential oil of Hedychium coronarium j. Koenig has neuroprotective effects in the pathogenesis of Alzheimer's disease by regulating lipid peroxidation and reducing oxidative stress in the brains of Aluminum chloride-treated mice and zebrafish, according to biochemical and histopathological studies. These findings suggest that Hedychium coronarium j. Koenig essential oil has anti-amnesic effects via acetylcholine esterase enzyme inhibition and modulation of oxidative stress indicators in neuronal cells. As a result, the current research also suggests that Hedychium coronarium j. Koenig may be used as a natural, complementary therapy for cognitive problems linked to Alzheimer's disease (AD).

Author Biographies

Shraddha Mahadev Parab

M. Pharm (Pharmacology), Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

Naikwade NS

Professor and HOD, Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

Shikalgar TS

Assistant Professor, Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

Rutuja Nandkumar Mali

M. Pharm (Pharmacology), Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

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Published

01-04-2024

How to Cite

Parab, S. M., NS, N., TS, S., & Mali, R. N. (2024). Cognition enhancing activity of essential oil of Hedychium coronarium j. Koenig in memory-impaired animal models. International Journal of Ayurvedic Medicine, 15(1), 180–191. https://doi.org/10.47552/ijam.v15i1.4415

Issue

Section

Research Articles