Evaluations of nephro-protective activity of poly-herbal hydroalcoholic extract against streptozotocin-induced nephrotoxicity and renal dysfunction

Abstract

Objective our research work aim was the assessment of the nephroprotective activity of poly-herbal hydroalcoholic extract against streptozotocin-induced nephrotoxicity and renal dysfunction. Poly-herbal hydroalcoholic extract of (PHHE) nephrotoxicity activity was determined using the streptozotocin-induced nephrotoxicity and renal dysfunction method. Poly-herbal hydroalcoholic extract of 200 and 300 mg/kg was given for eight weeks to selected animals rat models. The biochemical parameters like as lipid profile, renal functional, antioxidant enzyme level, anti-inflammatory factors and histopathological evaluations parameters were used for estimation of nephroprotective activity. PHHE also reduced the levels of creatinine, blood urea nitrogen, total cholesterol, triglycerides, advanced glycation end products and albumin in serum and urine, respectively. PHHE drastically increased the antioxidant parameters in the kidney and histological evaluation. All of these evaluations parameters results were exposed that PHEE has potential antioxidant, and anti-glycation activities. Exhibited significant therapeutic effects and was found to be the potential same as standard glimepiride drug. The experimental results were found to be significant nephroprotective action of PHHE extract on STZ induced diabetic nephroprotective animal model. Conclude the PHHE can use for the treatment and management of diabetic nephropathy disease.