Assessing the therapeutic potential of Banana blossom extract in ameliorating Mifepristone-Induced Polycystic Ovarian Syndrome in Rat Model

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a syndrome defined by ovarian dysfunction which is marked primarily by elevated hormone levels and the presence of polycystic ovaries discovered on ultrasonography. Polycystic ovarian syndrome is an extremely prevalent lifestyle disorder that affects 6 out of 10 women. The management of polycystic ovarian syndrome is largely unclear. This study examines the possible use of Banana Blossom an herbal therapy in a rat model of polycystic ovarian syndrome caused by the medication mifepristone. Methods: For 13 days, female Wistar rats were given 20mg/kg b.w. of mifepristone daily to induce PCOS, which was verified by the sustained estrous cycle. The rats received treatment with Banana Blossom extract orally for 21 days at a dosage of 200, 400 and 800mg/kg b.w. after PCOS induction and standard treatment was metformin. Physical, biochemical parameter and oxidative stress marker was carried out using standard procedure. Result: The PCOS rats reported a significant decline (P˂0.001) in uterine weight, HDL, SOD as well as GSH levels along with a significant rise (P˂0.001) in body weight, periovarian fat, LDL, triglycerides, MDA and glucose level. Banana Blossom extract reversed these effects, with the 800mg/kg b.w. dose providing the most significant improvements in oxidative stress markers and biochemical parameters. Conclusion: After analysing the data, one can conclude that the banana blossom ethanolic extract exhibited an improved therapeutic effect on mifepristone induced polycystic ovarian syndrome in female Wistar rats.