Neuroprotective assessment of methanolic root extract of Moringa Concanensis against Cisplatin-induced peripheral neuropathy in rats

Abstract

Objective: Investigation of the methanolic root extract of Moringa concanensis nimmo (MC) as a potential treatment for cisplatin-induced peripheral neuropathy in rats. Methods Male Albino Wistar rats were divided into 5 groups: Normal control, positive control, low dose MC root extract (200 mg / kg, p.o.), high dose MC root extract (400 mg / kg, p.o.), standard (Ascorbic acid) (45 mg / kg, p.o.). Cisplatin (2.5 mg / kg, ip) was administered in the second week and continued for 4 weeks, while MC root extract and ascorbic acid were administered orally from the first week for 5 weeks. After 5 weeks, Behavioural assessments, and antioxidant activity in sciatic nerve homogenate were performed. Histopathological analysis of sciatic nerve samples was performed using H&E stain. Results: Treatment with methanolic root extract of MC at low dose and high dose for 5 weeks significantly improved behavioral parameters, antioxidant levels, attenuated oxidative stress, and restored histopathological deterioration of sciatic nerve compared to the positive control group. However, grip strength and motor coordination of animals treated with standard showed no significant difference when compared to high dose. Conclusion: The study indicates that methanolic root extract of MC protects Cisplatin-Induced Peripheral Neuropathy in rats, as demonstrated by improved behavioral parameters, enhanced antioxidant levels, and restored histopathological features. MC root extract appears promising as a preventive measure for Cisplatin-Induced Peripheral Neuropathy, potentially benefiting cancer patients undergoing chemotherapy.