To Evaluate the Efficacy of Add on Treatment of Oral Drug Formulation With Agnikarma in the Management of Jaanu Sandhigata Vata W.S.R. To Osteoarthritis of Knee Joint – a Randomized Controlled Trial

Abstract

Background: Recent estimates suggest that OA affects approximately 7.6% of the globalpopulation, with knee OA being especially common among older adults. The combined approach of Agnikarma and oral drugs holds significant promise as an effective option forosteoarthritis. Objective: To Evaluate the Efficacy of Add on Treatment of Oral Drug Formulation with Agnikarma in The Management of Janu Sandhigata Vata W.S.R. to Osteoarthritis of Knee Joint. Materials and Methods: 40 subjects diagnosed with Janu Sandhigata Vata after fulfilling inclusion criteria were enrolled in the study. Agnikarma performed every 7th day (4 sittings) after obtaining informed consent according to the randomized groups i.e., Control group (Agnikarma) and Trial group (Agnikarma along with Oral drugs). The assessment parameters i.e., Pain, Tenderness, Swelling, Crepitus, ROM and Kellgren and Lawrence classification of Osteoarthritis were assessed from baseline and at different time points. Results: The results demonstrated significant improvements in the Trial group receiving combined treatment in all the parameters. Pain, Tenderness and ROM showed statisticallysignificant improvements, with the Trial group consistently outperforming the Control group. Conclusion: The Trial group (Agnikarma combined with oral drugs) demonstrated superior efficacy across most clinical parameters in improving pain, tenderness, and functional outcomes (range of movement), suggesting that the combined treatment provides significant benefits over Agnikarma alone in the management of Janu Sandhigata Vata. Clinical Significance: This study highlights the potential of a combined approach of Agnikarma and oral drugs as an effective intervention for osteoarthritis, providing meaningful improvements in pain and functionality over a short duration.