In Vivo Efficacy of Advanced Drug Delivery System Loaded with Different Medicaments For Regenerative Endodontics

Abstract

Aim: The aim of this study is to evaluate the efficacy of an advanced drug delivery system loaded with calcium hydroxide and calcium silicate for regenerative endodontic procedures. Materials & Methods: Preparation of Drug Delivery System: A biocompatible carrier material hydrogel is prepared which is capable of encapsulating calcium hydroxide and calcium silicate particles. Characterisation: The drug delivery system is characterised for its morphology and release kinetics. Animal Study: In vivo studies are conducted using animal models of pulpal injury or infection. The drug delivery system is applied in root canal procedures, and the regeneration of pulp tissue and formation of hard tissue barriers are assessed using histological and radiographic analyses. Results & Discussion: Sustained Release Property: The drug delivery system exhibits potent endodontics regeneration property with sustained release of calcium hydroxide contributing to effective bacterial elimination. Tissue Regeneration: The incorporation of calcium silicate promotes dentinogenesis and facilitates the formation of hard tissue barriers, leading to enhanced tissue regeneration within the root canal space. Conclusion: In conclusion, the advanced drug delivery system loaded with calcium hydroxide and calcium silicate shows great promise for enhancing regenerative endodontic procedures. Its ability to provide sustained release of medicaments, promote tissue regeneration, and improve treatment outcomes makes it a valuable tool in modern endodontic practice.