Ghrita and different herbal inclusions on neurological disorders - A perspective review

Abstract

Introduction: Ayurveda ghrita dosage forms are well appreciated in the Classical treatises for different diseases and may be useful in neurological conditions such as these formulations are recommended since birth for memory enhancement and improving intellect as the major development of brain completes within the initial 5 years. So, these PUFA embedded preparations with DHA, AA, BA, etc are extensively screened out for the cognition, memory, neuro-protective, genesis of plasticity, etc in terms of herbal constituents added with the dosage form. Material and Methods: The Classical Ayurveda treatises and the databases like Pubmed, Scopus, Web of Science, etc were searched with the words like nootropic, PUFA, DHA, etc. The articles related with synaptic transmission and the phytochemical domination in the neurotransmission were separated for further understanding of mechanism. Results: AChE inhibitory action can preserve the acetyl choline activity while the synaptic transmission exhibited by α-Asarone of AC, BM, etc. Similarly, the Glutamate transmission with the NMDA receptor protected the neuronal degeneration from β-Amyloid like protein accumulation in CP constituents. The Serotonergic and Dopaminergic neurotransmission pathway were also regulated by the herbal and the lipid factors. These different pathways were somehow involved in the memory enhancement. Conclusion: The ghrita and the herbals mentioned were maintaining the neuronal synaptic transmission. Further clarification is necessary regarding the intrinsic pathway related to the mechanism of ghrita dosage form.