Comparative evaluation of Punarnavadi guggul tablet formulation for anti-inflammatory activity

Abstract

Punarnavadi guggul represents a traditional polyherbal formulation utilized in the treatment of dermatological conditions, jaundice, dropsy, edema, hyperuricemia, and rheumatism. The present investigation sought a comparative analysis of the three marketed formulations of Punarnavadi Guggul tablet for its in vivo anti-inflammatory properties. The anti-inflammatory effects were assessed using the carrageenan-induced rat paw edema model and the cotton pellet granuloma method. The animal groups treated with laboratory-prepared formulation PF (150 mg/kg) showed significant antiinflammatory activity comparable to the standard drug. Existing literature indicates that guggulsterone E, Z, and deodarone are implicated in the anti-inflammatory effects, whereas gallic acid, ascorbic acid, polyphenols, and flavonoids contribute to its antioxidant properties. The formulated tablet exhibited pre-eminent anti-inflammatory properties when compared to commercial formulations, but all formulations showed noteworthy bioactivity.