Mahua Oil as a Promising Antipsoriatic Agent: Insights from In Vitro Studies
DOI:
https://doi.org/10.47552/ijam.v16iS2.6194Keywords:
Psoriasis, Mahua oil, GCMS, HaCaT cells, IL-1β, TNF-α, NF-κB, COX-IIAbstract
Psoriasis, a chronic autoimmune skin condition, aligns with the Ayurvedic classification of Kitibha, which results from vitiated Vata and Kapha doshas and the accumulation of Ama. This study investigates the therapeutic potential of Madhuca longifolia (Mahua) oil in the management of psoriasis. Organoleptic Evaluation, Physicochemical analysis (Acid Value, Saponification Value, Iodine Value) and Gas Chromatography-Mass Spectrometry (GC-MS) were performed To check authenticity and purity of the oil. In vitro evaluations on HaCaT keratinocyte cell lines were conducted to assess antiproliferative and anti-inflammatory activities. Results revealed that Mahua oil significantly reduced pro-inflammatory cytokines (IL-1β, TNF-α) and nuclear transcription factor NF-κB (p < 0.05). Furthermore, Mahua oil demonstrated inhibitory effects on COX-2 pathway, confirming its efficacy in modulating inflammatory responses. These findings support its traditional use and propose Mahua oil as a viable natural treatment for psoriasis.
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