Psychedelic Herbal Medicines: Exploring the Renaissance of a Therapeutic Frontier

Authors

  • Gaurav Mude Institute of Pharmaceutical Science, SAGE University, Indore (MP), India
  • Shantilal Singune Institute of Pharmaceutical Sciences, SAGE University, Indore (MP), India.
  • Raghvendra Dubey Institute of Pharmaceutical Sciences, SAGE University, Indore (MP), India.

DOI:

https://doi.org/10.47552/ijam.v16iS2.6197

Keywords:

Psychedelic Herbal Medicines, Neuroplasticity, Mental Health, Ethnobotany, Therapeutic Applications

Abstract

A revolutionary change in contemporary therapeutic paradigms may be seen in the renewed interest in psychedelic plant remedies. Psychedelic plants like psilocybe mushrooms, ayahuasca, iboga, and salvia divinorum, which have long been valued for their spiritual and therapeutic qualities in a variety of cultures, are now the subject of intense scientific research. According to recent clinical research, they have great promise for treating a variety of illnesses, such as addiction, PTSD, anxiety, and depression. This resurgence is fuelled by mounting evidence that these drugs may support profound psychological healing, emotional resilience, and neuroplasticity when used under careful supervision. Technological developments in ethnobotany, neurology, and psychopharmacology are revealing the intricate processes by which these herbal psychedelics work, particularly via serotonergic pathway regulation and the amplification of introspective experiences. The regulatory environment is gradually changing, indicating a cautious sense of hope about the incorporation of these traditional medicines into contemporary medical treatment. But there are still issues to be resolved, such as standardising botanical formulations, guaranteeing patient safety, and tackling the social stigma attached to psychedelics. This study highlights the need for multidisciplinary cooperation in furthering this exciting field by examining the historical origins, molecular foundations, therapeutic uses, and potential future developments of psychedelic plant medicines. Psychedelic herbal treatments provide a rare chance to rethink mental health therapy by fusing ancient wisdom with modern research, paving the door for more individualised and holistic approaches to recovery.

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Published

2025-07-21

How to Cite

Mude, G., Singune, S., & Dubey, R. (2025). Psychedelic Herbal Medicines: Exploring the Renaissance of a Therapeutic Frontier. International Journal of Ayurvedic Medicine, 16(S2), 1–9. https://doi.org/10.47552/ijam.v16iS2.6197