Pharmaceutical Standardization and Physicochemical Profile of Tamra Parpati

Abstract

Tamra Parpati (TP) is a herbo-metallic formulation described in the classical ayurvedic text Rasamritam and also mentioned in the Ayurvedic Formulary of India (AFI). This study aims to establish pharmaceutical standardization of Tamra Parpati along with its quality control parameters. Three batches of Tamra Parpati were prepared as per the classical method explained in the reference to evaluate the standard manufacturing procedure (SMP). Pharmaceutical procedures such as Shodhana (pre-processing) of Parada (mercury), Gandhaka (sulfur), Tamra (copper), Vatsanabha (Aconitum chasmanthum Stapf ex Holmes), preparation of TP and Physicochemical parameters were carried out at the Department of Rasa shastra and Bhaishajya Kalpana and at the pharmaceutical chemistry Lab, ITRA, Jamnagar, respectively. Three batches of TP after preparation showed an average increase of 1.11% yield. For melting 10.11g of material in all three batches, an average of 5.31 min was required, with the temperature of the Valuka Yantra (sand bath apparatus) at 284℃ and the temperature of the material at 127℃. Organoleptic characteristics reveal soft and smooth to the touch, black, tasteless, and smell like SO2 when ground. Mean ± standard deviation (SD) of pH (1% solution), loss on drying, ash value, Loss on ignition, acid insoluble ash, CS2 soluble extractive, Benzene extractive, water soluble extractive, and alcohol soluble extractive of TP was 7±0.00, 0.501±0.0784 %w/w, 13.947±0.244%w/w, 85.651±0.896%w/w, 11.397±0.529%w/w, 15.689±1.663%w/w, 12.737±0.605%w/w, 2.388±0.252%w/w and 3.232±0.207%w/w, respectively. The data obtained from the pharmaceutical study and physicochemical parameters may be used for future pharmacological evaluation and clinical validation of Tamra Parpati.