TY - JOUR AU - B, Pooja AU - K, Govinda Sharma AU - Kadibagil, Vinay R PY - 2022/07/08 Y2 - 2024/03/29 TI - Formulation and evaluation of antifungal activity of Kasisadi Varti against Candida albicans JF - International Journal of Ayurvedic Medicine JA - IJAM VL - 13 IS - 2 SE - Research Articles DO - UR - https://ijam.co.in/index.php/ijam/article/view/2565 SP - 412-418 AB - <p>Background: Medicine is said to be of good quality when it gives the desired therapeutic effect and at the same time does not cause any harm to the patients. The safety and efficacy of a medicine is of at most importance. Preclinical studies play a vital role in ascertaining the safety and efficacy of a drug before taking it for clinical trial. They mainly involve invitro and invivo models. <em>Kasisadi churna</em> is a formulation mentioned for external application in <em>kaphaja yoni vyapath</em>. Application of <em>churna </em>(powder) externally may not be compatible on patients, and hence the dosage form was modified into <em>varti</em> (suppository) form. Objective: Invitro study to asses antifungal activity of <em>kasisadi varti. </em>Material and Methods: <em>Kasisadi varti</em> were prepared in three different methods. They were assessed for activity against <em>Candida albicans</em> by invitro Agar well diffusion method at different concentrations 32mg/dl, 64mg/dl, 128mg/dl, 256mg/dl and 512 mg/dl. Result: All three samples showed significant activity against <em>Candida albicans</em> at a concentration of 128 mg/dl, 256mg/dl and 512mg/dl. Conclusion:All three samples showed significant results on <em>Candida albicans</em> developed from vaginal smears of patients at a concentration of 128mg/ml, 256mg/ml, and 512 mg/ml in comparison with standard drug Amphotericin B. None of the samples showed any effect on MTCC Strain of <em>Candida albicans.</em></p> ER -