TY - JOUR AU - Ware, Rajashri AU - Chavhan, Santosh G AU - Gatphane, Rupali AU - Denge, Kalpana PY - 2023/01/07 Y2 - 2024/03/29 TI - A pilot study to observe the progression of Vyadhi Samprapti in Srotas in the context of Hypothyroidism JF - International Journal of Ayurvedic Medicine JA - IJAM VL - 13 IS - 4 SE - Research Articles DO - 10.47552/ijam.v13i4.3094 UR - https://ijam.co.in/index.php/ijam/article/view/3094 SP - 1114-1120 AB - <p>In chronic conditions, the progression of<em> samprapti</em> (pathogenesis) of Hypothyroidism in various <em>Srotasas </em>(Body Channels) can be observed due to the lack of <em>Nidanparivarjanam </em>(restraining of etiological factor) and <em>Shuddha-Chikitsa </em>(Comprehensive treatment). Assessment of the progression of the pathogenesis of Hypothyroidism in the <em>Srotasas </em>would help to decide the treatment plan for Hypothyroidism according to the stage of the disease, which prevents the further progression of the disease and drug dependency. Objectives: Observe the progression of the pathogenesis of Hypothyroidism in the <em>Srotasas </em>by assessing signs and symptoms of the <em>Dhatupradoshaja Vikara </em>(diseases due to vitiation of <em>dhatu</em>) along with their severity. Methods: In a cross-sectional study, 50 patients with chronicity of hypothyroidism for more than 1 year and on therapy were selected randomly and categorized into 5 groups, according to their chronicity. A separate case proforma was designed to focus on the assessment of the progression of the pathogenesis in patients of Hypothyroidism. The signs and symptoms described as <em>Dhatupradoshaja Vikara,</em> chronicity of hypothyroidism, findings of Thyroid Function Test (total serum thyroid-stimulating hormone, serum, total serum triiodothyronine, total serum thyroxine,) and drug dosage were recorded in each patient. The data was subjected to statistical tests.  Results: It is observed that the extent of signs and symptoms of <em>Dhatupradoshaja Vikaras</em> increased with the chronicity of Hypothyroidism in study participants. Progression of <em>Samprapti</em> of hypothyroidism in further<em> Srotasa</em> was observed in patients with chronicity of Hypothyroidism, especially in individuals with <em>Avar</em> <em>Agni</em> (weak state of digestive and metabolic factors). It is observed that in the study participant drug dosages were escalated with chronicity and <em>Avara Agnibala </em>(weak state of <em>Agni</em>).  <em>Rasadhatu</em> and <em>Rasavaha Srotas</em> along with <em>Medodhatu</em> and <em>Medovaha Srotas</em> are priorly and predominantly get vitiated in the <em>Samprapti </em>while other <em>Dhatus</em> and <em>Dhatuvaha Srotasa</em> are involved in <em>Samprapti </em>over the period. Conclusion: It can be concluded that the <em>vyadhi samprapti</em> of Hypothyroidism progresses in further <em>Srotasa</em> with the chronicity of hypothyroidism.<span class="Apple-converted-space"> </span></p> ER -